Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response

Clearance of mitochondria following damage is critical for neuronal homeostasis. Here, we investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin mitochondrial quality control system in vitro and in vivo. We find that upon mitochondrial damage, Miro is promiscuously ubiqu...

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Detalles Bibliográficos
Autores principales: López‐Doménech, Guillermo, Howden, Jack H, Covill‐Cooke, Christian, Morfill, Corinne, Patel, Jigna V, Bürli, Roland, Crowther, Damian, Birsa, Nicol, Brandon, Nicholas J, Kittler, Josef T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280823/
https://www.ncbi.nlm.nih.gov/pubmed/34152608
http://dx.doi.org/10.15252/embj.2018100715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280823/
https://www.ncbi.nlm.nih.gov/pubmed/34152608
http://dx.doi.org/10.15252/embj.2018100715

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