The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health

Recent research demonstrates a reciprocal relationship between gut microbiota-derived metabolites and the host in controlling the energy homeostasis in mammals. On the one hand, to thrive, gut bacteria exploit nutrients digested by the host. On the other hand, the host utilizes numerous products of...

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Autores principales: Tomasova, Lenka, Grman, Marian, Ondrias, Karol, Ufnal, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281717/
https://www.ncbi.nlm.nih.gov/pubmed/34266472
http://dx.doi.org/10.1186/s12986-021-00598-5
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author Tomasova, Lenka
Grman, Marian
Ondrias, Karol
Ufnal, Marcin
author_facet Tomasova, Lenka
Grman, Marian
Ondrias, Karol
Ufnal, Marcin
author_sort Tomasova, Lenka
collection PubMed
description Recent research demonstrates a reciprocal relationship between gut microbiota-derived metabolites and the host in controlling the energy homeostasis in mammals. On the one hand, to thrive, gut bacteria exploit nutrients digested by the host. On the other hand, the host utilizes numerous products of gut bacteria metabolism as a substrate for ATP production in the colon. Finally, bacterial metabolites seep from the gut into the bloodstream and interfere with the host’s cellular bioenergetics machinery. Notably, there is an association between alterations in microbiota composition and the development of metabolic diseases and their cardiovascular complications. Some metabolites, like short-chain fatty acids and trimethylamine, are considered markers of cardiometabolic health. Others, like hydrogen sulfide and nitrite, demonstrate antihypertensive properties. Scientific databases were searched for pre-clinical and clinical studies to summarize current knowledge on the role of gut microbiota metabolites in the regulation of mammalian bioenergetics and discuss their potential involvement in the development of cardiometabolic disorders. Overall, the available data demonstrates that gut bacteria products affect physiological and pathological processes controlling energy and vascular homeostasis. Thus, the modulation of microbiota-derived metabolites may represent a new approach for treating obesity, hypertension and type 2 diabetes.
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spelling pubmed-82817172021-07-16 The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health Tomasova, Lenka Grman, Marian Ondrias, Karol Ufnal, Marcin Nutr Metab (Lond) Review Recent research demonstrates a reciprocal relationship between gut microbiota-derived metabolites and the host in controlling the energy homeostasis in mammals. On the one hand, to thrive, gut bacteria exploit nutrients digested by the host. On the other hand, the host utilizes numerous products of gut bacteria metabolism as a substrate for ATP production in the colon. Finally, bacterial metabolites seep from the gut into the bloodstream and interfere with the host’s cellular bioenergetics machinery. Notably, there is an association between alterations in microbiota composition and the development of metabolic diseases and their cardiovascular complications. Some metabolites, like short-chain fatty acids and trimethylamine, are considered markers of cardiometabolic health. Others, like hydrogen sulfide and nitrite, demonstrate antihypertensive properties. Scientific databases were searched for pre-clinical and clinical studies to summarize current knowledge on the role of gut microbiota metabolites in the regulation of mammalian bioenergetics and discuss their potential involvement in the development of cardiometabolic disorders. Overall, the available data demonstrates that gut bacteria products affect physiological and pathological processes controlling energy and vascular homeostasis. Thus, the modulation of microbiota-derived metabolites may represent a new approach for treating obesity, hypertension and type 2 diabetes. BioMed Central 2021-07-15 /pmc/articles/PMC8281717/ /pubmed/34266472 http://dx.doi.org/10.1186/s12986-021-00598-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Tomasova, Lenka
Grman, Marian
Ondrias, Karol
Ufnal, Marcin
The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health
title The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health
title_full The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health
title_fullStr The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health
title_full_unstemmed The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health
title_short The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health
title_sort impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281717/
https://www.ncbi.nlm.nih.gov/pubmed/34266472
http://dx.doi.org/10.1186/s12986-021-00598-5
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