ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions

SARS-CoV-2 uses the human ACE2 (hACE2) receptor for cell attachment and entry, with mouse ACE2 (mACE2) unable to support infection. Herein we describe an ACE2-lentivirus system and illustrate its utility for in vitro and in vivo SARS-CoV-2 infection models. Transduction of non-permissive cell lines...

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Detalles Bibliográficos
Autores principales: Rawle, Daniel J., Le, Thuy T., Dumenil, Troy, Yan, Kexin, Tang, Bing, Nguyen, Wilson, Watterson, Daniel, Modhiran, Naphak, Hobson-Peters, Jody, Bishop, Cameron, Suhrbier, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282004/
https://www.ncbi.nlm.nih.gov/pubmed/34214142
http://dx.doi.org/10.1371/journal.ppat.1009723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282004/
https://www.ncbi.nlm.nih.gov/pubmed/34214142
http://dx.doi.org/10.1371/journal.ppat.1009723

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