Prediction of Alternative Drug-Induced Liver Injury Classifications Using Molecular Descriptors, Gene Expression Perturbation, and Toxicology Reports

Motivation: Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI, based on the chemical properties of substances and experiments performed on cell lines, would bring a significant reduction in the cost of clinical trials and faster development...

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Detalles Bibliográficos
Autores principales: Lesiński, Wojciech, Mnich, Krzysztof, Rudnicki, Witold R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282233/
https://www.ncbi.nlm.nih.gov/pubmed/34276771
http://dx.doi.org/10.3389/fgene.2021.661075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282233/
https://www.ncbi.nlm.nih.gov/pubmed/34276771
http://dx.doi.org/10.3389/fgene.2021.661075

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