Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology

Inhibition of the protein phosphatase calcineurin (CN) ameliorates pathophysiologic and cognitive changes in aging rodents and mice with aging‐related Alzheimer's disease (AD)‐like pathology. However, concerns over adverse effects have slowed the transition of common CN‐inhibiting drugs to the...

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Detalles Bibliográficos
Autores principales: Sompol, Pradoldej, Gollihue, Jenna L., Kraner, Susan D., Artiushin, Irina A., Cloyd, Ryan A., Chishti, Emad A., Koren, Shon A., Nation, Grant K., Abisambra, Jose F., Huzian, Orsolya, Nagy, Lajos I., Santha, Miklos, Hackler, Laszlo, Puskas, Laszlo G., Norris, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282246/
https://www.ncbi.nlm.nih.gov/pubmed/34117818
http://dx.doi.org/10.1111/acel.13416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282246/
https://www.ncbi.nlm.nih.gov/pubmed/34117818
http://dx.doi.org/10.1111/acel.13416

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