Nucleotide‐binding domain and leucine‐rich‐repeat‐containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung‐like changes

Mitochondrial dysfunction has long been implicated to have a causative role in organismal aging. A mitochondrial molecule, nucleotide‐binding domain and leucine‐rich‐repeat‐containing protein X1 (NLRX1), represents the only NLR family member that targets this cellular location, implying that NLRX1 p...

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Detalles Bibliográficos
Autores principales: Shin, Hyeon Jun, Kim, Sang‐Hun, Park, Hong‐Jai, Shin, Min‐Sun, Kang, Insoo, Kang, Min‐Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282248/
https://www.ncbi.nlm.nih.gov/pubmed/34087956
http://dx.doi.org/10.1111/acel.13410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282248/
https://www.ncbi.nlm.nih.gov/pubmed/34087956
http://dx.doi.org/10.1111/acel.13410

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