Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP

YiiP is a secondary transporter that couples Zn(2+) transport to the proton motive force. Structural studies of YiiP from prokaryotes and Znt8 from humans have revealed three different Zn(2+) sites and a conserved homodimeric architecture. These structures define the inward-facing and outward-facing...

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Detalles Bibliográficos
Autores principales: Lopez-Redondo, Maria, Fan, Shujie, Koide, Akiko, Koide, Shohei, Beckstein, Oliver, Stokes, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282283/
https://www.ncbi.nlm.nih.gov/pubmed/34254979
http://dx.doi.org/10.1085/jgp.202112873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282283/
https://www.ncbi.nlm.nih.gov/pubmed/34254979
http://dx.doi.org/10.1085/jgp.202112873

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