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Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
Previous GWAS studies identified non-coding loci with parent-of-origin-specific effects on Type 2 diabetes susceptibility. Here we report the molecular basis for one such locus near the KRTAP5-6 gene on chromosome 11. We determine the pattern of long-range contacts between an enhancer in this locus...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282625/ https://www.ncbi.nlm.nih.gov/pubmed/34267199 http://dx.doi.org/10.1038/s41467-021-24635-2 |