Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins

Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs), but specific interaction with and regulation by PIPs for most PH domain-containing proteins are unclear. Here we employ a single-molecule pulldown assay to study interactions of lipid vesicles with full-length proteins i...

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Detalles Bibliográficos
Autores principales: Singh, Nilmani, Reyes-Ordoñez, Adriana, Compagnone, Michael A., Moreno, Jesus F., Leslie, Benjamin J., Ha, Taekjip, Chen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282632/
https://www.ncbi.nlm.nih.gov/pubmed/34267198
http://dx.doi.org/10.1038/s41467-021-24639-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282632/
https://www.ncbi.nlm.nih.gov/pubmed/34267198
http://dx.doi.org/10.1038/s41467-021-24639-y

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