Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

Agonistic profiles of AMPA receptor (AMPA-R) potentiators may be associated with seizure risk and bell-shaped dose-response effects. Here, we report the pharmacological characteristics of a novel AMPA-R potentiator, TAK-653, which exhibits minimal agonistic properties. TAK-653 bound to the ligand bi...

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Detalles Bibliográficos
Autores principales: Suzuki, Atsushi, Kunugi, Akiyoshi, Tajima, Yasukazu, Suzuki, Noriko, Suzuki, Motohisa, Toyofuku, Masashi, Kuno, Haruhiko, Sogabe, Satoshi, Kosugi, Yohei, Awasaki, Yasuyuki, Kaku, Tomohiro, Kimura, Haruhide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282797/
https://www.ncbi.nlm.nih.gov/pubmed/34267258
http://dx.doi.org/10.1038/s41598-021-93888-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282797/
https://www.ncbi.nlm.nih.gov/pubmed/34267258
http://dx.doi.org/10.1038/s41598-021-93888-0

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