GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis

Ferroptosis, a newly defined mode of regulated cell death caused by unbalanced lipid redox metabolism, is implicated in various tissue injuries and tumorigenesis. However, the role of ferroptosis in stem cells has not yet been investigated. Glutathione peroxidase 4 (GPX4) is a critical suppressor of...

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Detalles Bibliográficos
Autores principales: Hu, Qian, Zhang, Yifan, Lou, Huiling, Ou, Zexian, Liu, Jin, Duan, Wentao, Wang, Hao, Ge, Yuanlong, Min, Junxia, Wang, Fudi, Ju, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282880/
https://www.ncbi.nlm.nih.gov/pubmed/34267193
http://dx.doi.org/10.1038/s41419-021-04008-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282880/
https://www.ncbi.nlm.nih.gov/pubmed/34267193
http://dx.doi.org/10.1038/s41419-021-04008-9

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