Intratumor morphologic and transcriptomic heterogeneity in (V600E)BRAF-mutated metastatic colorectal adenocarcinomas

BACKGROUND: Intratumor heterogeneity (ITH) is described as the presence of various clones within one tumor, each with their own unique features in terms of morphology, inflammation, genetics or transcriptomics. Heterogeneity provides the fuel for drug resistance; therefore, an accurate assessment of...

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Detalles Bibliográficos
Autores principales: Angerilli, V., Fontana, E., Lonardi, S., Sbaraglia, M., Borelli, B., Munari, G., Salmaso, R., Guzzardo, V., Spolverato, G., Pucciarelli, S., Pilati, P., Hahne, J.C., Bergamo, F., Zagonel, V., Dei Tos, A.P., Sadanandam, A., Loupakis, F., Valeri, N., Fassan, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282957/
https://www.ncbi.nlm.nih.gov/pubmed/34271310
http://dx.doi.org/10.1016/j.esmoop.2021.100211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282957/
https://www.ncbi.nlm.nih.gov/pubmed/34271310
http://dx.doi.org/10.1016/j.esmoop.2021.100211

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