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Investigation of nonsynonymous mutations in the spike protein of SARS-CoV-2 and its interaction with the ACE2 receptor by molecular docking and MM/GBSA approach

COVID-19 is an infectious and pathogenic viral disease caused by SARS-CoV-2 that leads to septic shock, coagulation dysfunction, and acute respiratory distress syndrome. The spreading rate of SARS-CoV-2 is higher than MERS-CoV and SARS-CoV. The receptor-binding domain (RBD) of the Spike-protein (S-p...

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Detalles Bibliográficos
Autores principales: Aljindan, Reem Y., Al-Subaie, Abeer M., Al-Ohali, Ahoud I., Kumar D, Thirumal, Doss C, George Priya, Kamaraj, Balu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282961/
https://www.ncbi.nlm.nih.gov/pubmed/34346317
http://dx.doi.org/10.1016/j.compbiomed.2021.104654