Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy

Repeated pairings of a neutral context and the effects of haloperidol give rise to conditioned catalepsy when the context is subsequently presented in a drug-free test. In order to confirm whether this response is based on Pavlovian processes, we conducted two experiments involving two manipulations...

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Autores principales: Cárcel, Lucía, De la Casa, Luis G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283013/
https://www.ncbi.nlm.nih.gov/pubmed/34276319
http://dx.doi.org/10.3389/fnbeh.2021.713512
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author Cárcel, Lucía
De la Casa, Luis G.
author_facet Cárcel, Lucía
De la Casa, Luis G.
author_sort Cárcel, Lucía
collection PubMed
description Repeated pairings of a neutral context and the effects of haloperidol give rise to conditioned catalepsy when the context is subsequently presented in a drug-free test. In order to confirm whether this response is based on Pavlovian processes, we conducted two experiments involving two manipulations that affect conditioning intensity in classical conditioning procedures: time of joint exposure to the conditioned and the unconditioned stimulus, and the length of the inter-stimulus interval (ISI). The results revealed that both an increase in the length of context-drug pairings during conditioning and a reduced ISI between drug administration and context exposure increased conditioned catalepsy. These results are discussed in terms of the temporal peculiarities of those procedures that involve drugs as the unconditioned stimulus along with the role of Pavlovian conditioning in context-dependent catalepsy.
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spelling pubmed-82830132021-07-17 Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy Cárcel, Lucía De la Casa, Luis G. Front Behav Neurosci Neuroscience Repeated pairings of a neutral context and the effects of haloperidol give rise to conditioned catalepsy when the context is subsequently presented in a drug-free test. In order to confirm whether this response is based on Pavlovian processes, we conducted two experiments involving two manipulations that affect conditioning intensity in classical conditioning procedures: time of joint exposure to the conditioned and the unconditioned stimulus, and the length of the inter-stimulus interval (ISI). The results revealed that both an increase in the length of context-drug pairings during conditioning and a reduced ISI between drug administration and context exposure increased conditioned catalepsy. These results are discussed in terms of the temporal peculiarities of those procedures that involve drugs as the unconditioned stimulus along with the role of Pavlovian conditioning in context-dependent catalepsy. Frontiers Media S.A. 2021-07-02 /pmc/articles/PMC8283013/ /pubmed/34276319 http://dx.doi.org/10.3389/fnbeh.2021.713512 Text en Copyright © 2021 Cárcel and De la Casa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cárcel, Lucía
De la Casa, Luis G.
Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy
title Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy
title_full Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy
title_fullStr Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy
title_full_unstemmed Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy
title_short Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy
title_sort temporal factors modulate haloperidol-induced conditioned catalepsy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283013/
https://www.ncbi.nlm.nih.gov/pubmed/34276319
http://dx.doi.org/10.3389/fnbeh.2021.713512
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