Therapeutic benefits of recombinant alpha1-antitrypsin IgG1 Fc-fusion protein in experimental emphysema

BACKGROUND: Alpha-1 antitrypsin (AAT) is a major serine protease inhibitor. AAT deficiency (AATD) is a genetic disorder characterized by early-onset severe emphysema. In well-selected AATD patients, therapy with plasma-derived AAT (pAAT), “augmentation therapy”, provides modest clinical improvement...

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Detalles Bibliográficos
Autores principales: Takeda, Katsuyuki, Kim, Soo-Hyun, Joetham, Anthony, Petrache, Irina, Gelfand, Erwin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283905/
https://www.ncbi.nlm.nih.gov/pubmed/34271910
http://dx.doi.org/10.1186/s12931-021-01784-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283905/
https://www.ncbi.nlm.nih.gov/pubmed/34271910
http://dx.doi.org/10.1186/s12931-021-01784-y

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