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Females, but not males, require protein degradation in the hippocampus for contextual fear memory formation

Strong evidence supports a role for protein degradation in fear memory formation. However, these data have been largely done in only male animals. Here, we found that following contextual fear conditioning, females, but not males, had increased levels of proteasome activity and K48 polyubiquitin pro...

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Detalles Bibliográficos
Autores principales: Martin, Kiley, Musaus, Madeline, Navabpour, Shaghayegh, Gustin, Aspen, Ray, W. Keith, Helm, Richard F., Jarome, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284313/
https://www.ncbi.nlm.nih.gov/pubmed/34266989
http://dx.doi.org/10.1101/lm.053429.121