Cyclic oligoadenylate signaling and regulation by ring nucleases during type III CRISPR defense

In prokaryotes, CRISPR-Cas immune systems recognize and cleave foreign nucleic acids to defend against mobile genetic elements (MGEs). Type III CRISPR-Cas complexes also synthesize cyclic oligoadenylate (cOA) second messengers, which activate CRISPR ancillary proteins involved in antiviral defense....

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Detalles Bibliográficos
Autores principales: Athukoralage, Januka S., White, Malcolm F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284326/
https://www.ncbi.nlm.nih.gov/pubmed/33986148
http://dx.doi.org/10.1261/rna.078739.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284326/
https://www.ncbi.nlm.nih.gov/pubmed/33986148
http://dx.doi.org/10.1261/rna.078739.121

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