Endothelial Nox2 Limits Systemic Inflammation and Hypotension in Endotoxemia by Controlling Expression of Toll-Like Receptor 4

Leukocyte Nox2 is recognized to have a fundamental microbicidal function in sepsis but the specific role of Nox2 in endothelial cells (EC) remains poorly elucidated. Here, we tested the hypothesis that endothelial Nox2 participates in the pathogenesis of systemic inflammation and hypotension induced...

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Detalles Bibliográficos
Autores principales: Trevelin, Silvia Cellone, Sag, Can Martin, Zhang, Min, Alves-Filho, José Carlos, Cunha, Thiago Mattar, dos Santos, Célio Xavier, Sawyer, Greta, Murray, Thomas, Brewer, Alison, Laurindo, Francisco Rafael Martins, Protti, Andrea, Lopes, Lucia Rossetti, Ivetic, Aleksandar, Cunha, Fernando Queiroz, Shah, Ajay M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Basic Science Aspects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284354/
https://www.ncbi.nlm.nih.gov/pubmed/34276040
http://dx.doi.org/10.1097/SHK.0000000000001706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284354/
https://www.ncbi.nlm.nih.gov/pubmed/34276040
http://dx.doi.org/10.1097/SHK.0000000000001706

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