Safety, Tolerability, and Population Pharmacokinetics of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients

Isavuconazole, administered as the water-soluble prodrug isavuconazonium sulfate, is a new triazole agent used to treat invasive fungal infections. This phase 1 study evaluated the pharmacokinetics (PK), safety, and tolerability of isavuconazole in 46 immunocompromised pediatric patients, stratified...

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Detalles Bibliográficos
Autores principales: Arrieta, Antonio C., Neely, Michael, Day, J. Christopher, Rheingold, Susan R., Sue, Paul K., Muller, William J., Danziger-Isakov, Lara A., Chu, Julie, Yildirim, Inci, McComsey, Grace A., Frangoul, Haydar A., Chen, Tempe K., Statler, Victoria A., Steinbach, William J., Yin, Dwight E., Hamed, Kamal, Jones, Mark E., Lademacher, Christopher, Desai, Amit, Micklus, Kelley, Phillips, Desiree Leiva, Kovanda, Laura L., Walsh, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284446/
https://www.ncbi.nlm.nih.gov/pubmed/34031051
http://dx.doi.org/10.1128/AAC.00290-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284446/
https://www.ncbi.nlm.nih.gov/pubmed/34031051
http://dx.doi.org/10.1128/AAC.00290-21

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