Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent against Strains of Enterobacterales Expressing Extended-Spectrum β-Lactamases and Serine Carbapenemases

There is an urgent need for oral agents to combat resistant Gram-negative pathogens. Here, we describe the characterization of VNRX-5236, a broad-spectrum boronic acid β-lactamase inhibitor (BLI), and its orally bioavailable etzadroxil prodrug, VNRX-7145. VNRX-7145 is being developed in combination...

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Detalles Bibliográficos
Autores principales: Chatwin, Cassandra L., Hamrick, Jodie C., Trout, Robert E. L., Myers, Cullen L., Cusick, Susan M., Weiss, William J., Pulse, Mark E., Xerri, Luigi, Burns, Christopher J., Moeck, Gregory, Daigle, Denis M., John, Kaitlyn, Uehara, Tsuyoshi, Pevear, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284453/
https://www.ncbi.nlm.nih.gov/pubmed/34001510
http://dx.doi.org/10.1128/AAC.00552-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284453/
https://www.ncbi.nlm.nih.gov/pubmed/34001510
http://dx.doi.org/10.1128/AAC.00552-21

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