Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus

New, more-effective drugs for the treatment of lung disease caused by nontuberculous mycobacteria (NTM) are needed. Among NTM opportunistic pathogens, Mycobacterium abscessus is the most difficult to cure and intrinsically multidrug resistant. In a whole-cell screen of a compound collection active a...

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Detalles Bibliográficos
Autores principales: Negatu, Dereje Abate, Beuchel, Andreas, Madani, Abdeldjalil, Alvarez, Nadine, Chen, Chao, Aragaw, Wassihun Wedajo, Zimmerman, Matthew D., Laleu, Benoît, Gengenbacher, Martin, Dartois, Véronique, Imming, Peter, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284461/
https://www.ncbi.nlm.nih.gov/pubmed/34001512
http://dx.doi.org/10.1128/AAC.00676-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284461/
https://www.ncbi.nlm.nih.gov/pubmed/34001512
http://dx.doi.org/10.1128/AAC.00676-21

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