Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage

Aging is associated with dysregulated immune functions. Here, we investigated the impact of age on neutrophil diapedesis. Using confocal intravital microscopy, we found that in aged mice, neutrophils adhered to vascular endothelium in inflamed tissues but exhibited a high frequency of reverse transe...

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Detalles Bibliográficos
Autores principales: Barkaway, Anna, Rolas, Loïc, Joulia, Régis, Bodkin, Jennifer, Lenn, Tchern, Owen-Woods, Charlotte, Reglero-Real, Natalia, Stein, Monja, Vázquez-Martínez, Laura, Girbl, Tamara, Poston, Robin N., Golding, Matthew, Saleeb, Rebecca S., Thiriot, Aude, von Andrian, Ulrich H., Duchene, Johan, Voisin, Mathieu-Benoit, Bishop, Cleo L., Voehringer, David, Roers, Axel, Rot, Antal, Lämmermann, Tim, Nourshargh, Sussan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284598/
https://www.ncbi.nlm.nih.gov/pubmed/34033752
http://dx.doi.org/10.1016/j.immuni.2021.04.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284598/
https://www.ncbi.nlm.nih.gov/pubmed/34033752
http://dx.doi.org/10.1016/j.immuni.2021.04.025

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