Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection

SARS-CoV and SARS-CoV-2 encode spike proteins that bind human ACE2 on the cell surface to enter target cells during infection. A small fraction of humans encode variants of ACE2, thus altering the biochemical properties at the protein interaction interface. These and other ACE2 coding mutants can re...

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Detalles Bibliográficos
Autores principales: Shukla, Nidhi, Roelle, Sarah M., Suzart, Vinicius G., Bruchez, Anna M., Matreyek, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284657/
https://www.ncbi.nlm.nih.gov/pubmed/34270613
http://dx.doi.org/10.1371/journal.ppat.1009715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284657/
https://www.ncbi.nlm.nih.gov/pubmed/34270613
http://dx.doi.org/10.1371/journal.ppat.1009715

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