Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies

Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and plays important roles in the viral life cycle. Being a large, multidomain, transmembrane protein, Nsp3 has been the most challenging Nsp to characterize. Encoded within Nsp3 is the papain-like protease domain (PL...

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Detalles Bibliográficos
Autores principales: Armstrong, Lee A., Lange, Sven M., Dee Cesare, Virginia, Matthews, Stephen P., Nirujogi, Raja Sekhar, Cole, Isobel, Hope, Anthony, Cunningham, Fraser, Toth, Rachel, Mukherjee, Rukmini, Bojkova, Denisa, Gruber, Franz, Gray, David, Wyatt, Paul G., Cinatl, Jindrich, Dikic, Ivan, Davies, Paul, Kulathu, Yogesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284666/
https://www.ncbi.nlm.nih.gov/pubmed/34270554
http://dx.doi.org/10.1371/journal.pone.0253364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284666/
https://www.ncbi.nlm.nih.gov/pubmed/34270554
http://dx.doi.org/10.1371/journal.pone.0253364

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