Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake

Niemann-Pick C1-like 1 (NPC1L1) protein plays a central role in the intestinal cholesterol absorption and is the target of a drug, ezetimibe, which inhibits NPC1L1 to reduce cholesterol absorption. Here, we present cryo–electron microscopy structures of human NPC1L1 in apo state, cholesterol-enriche...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Miaoqing, Yang, Fan, Huang, Yawen, You, Xin, Liu, Desheng, Sun, Shan, Sui, Sen-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284890/
https://www.ncbi.nlm.nih.gov/pubmed/34272236
http://dx.doi.org/10.1126/sciadv.abg3188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284890/
https://www.ncbi.nlm.nih.gov/pubmed/34272236
http://dx.doi.org/10.1126/sciadv.abg3188

Ejemplares similares