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Multivariate data analysis of capacitance frequency scanning for online monitoring of viable cell concentrations in small-scale bioreactors

Viable cell concentration (VCC) is one of the most important process attributes during mammalian cell cultivations. Current state-of-the-art measurements of VCC comprise offline methods which do not allow for continuous process data. According to the FDA’s process analytical technology initiative, p...

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Detalles Bibliográficos
Autores principales: Metze, Sabrina, Blioch, Stefanie, Matuszczyk, Jens, Greller, Gerhard, Grimm, Christian, Scholz, Jochen, Hoehse, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285309/
https://www.ncbi.nlm.nih.gov/pubmed/31608427
http://dx.doi.org/10.1007/s00216-019-02096-3