Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer

Various genetic alterations of the fibroblast growth factor receptor (FGFR) family have been detected across a wide range of cancers. However, inhibition of FGFR signaling by kinase inhibitors demonstrated limited clinical effectiveness. Herein, we evaluated the transforming activity and sensitivity...

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Detalles Bibliográficos
Autores principales: Nakamura, Ikuko Takeda, Kohsaka, Shinji, Ikegami, Masachika, Ikeuchi, Hiroshi, Ueno, Toshihide, Li, Kunhua, Beyett, Tyler S., Koyama, Takafumi, Shimizu, Toshio, Yamamoto, Noboru, Takahashi, Fumiyuki, Takahashi, Kazuhisa, Eck, Michael J., Mano, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285406/
https://www.ncbi.nlm.nih.gov/pubmed/34272467
http://dx.doi.org/10.1038/s41698-021-00204-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285406/
https://www.ncbi.nlm.nih.gov/pubmed/34272467
http://dx.doi.org/10.1038/s41698-021-00204-0

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