USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis

Understanding the mechanisms underlying evasive resistance in cancer is an unmet medical need to improve the efficacy of current therapies. In hepatocellular carcinoma (HCC), aberrant expression of hypoxia-inducible factor 1 α (HIF1α) and increased aerobic glycolysis metabolism are drivers of resist...

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Detalles Bibliográficos
Autores principales: Gao, Ruize, Buechel, David, Kalathur, Ravi K. R., Morini, Marco F., Coto-Llerena, Mairene, Ercan, Caner, Piscuoglio, Salvatore, Chen, Qian, Blumer, Tanja, Wang, Xueya, Dazert, Eva, Heim, Markus H., Hall, Michael N., Tang, Fengyuan, Christofori, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285469/
https://www.ncbi.nlm.nih.gov/pubmed/34272356
http://dx.doi.org/10.1038/s41389-021-00338-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285469/
https://www.ncbi.nlm.nih.gov/pubmed/34272356
http://dx.doi.org/10.1038/s41389-021-00338-7

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