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Tumour heterogeneity and evolutionary dynamics in colorectal cancer
Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC has progressed from initial discoveries which focused on the stepwise accumulation of key driver mutations, as encapsulated in the Vogelstein model, to one in which marked heterogeneity leads to a complex interp...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285471/ https://www.ncbi.nlm.nih.gov/pubmed/34272358 http://dx.doi.org/10.1038/s41389-021-00342-x |