Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in cancer cells that express elevated levels of both proteins. The mechanisms by which velcrins induce complex formation, and how the PDE3A-S...

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Detalles Bibliográficos
Autores principales: Garvie, Colin W., Wu, Xiaoyun, Papanastasiou, Malvina, Lee, Sooncheol, Fuller, James, Schnitzler, Gavin R., Horner, Steven W., Baker, Andrew, Zhang, Terry, Mullahoo, James P., Westlake, Lindsay, Hoyt, Stephanie H., Toetzl, Marcus, Ranaghan, Matthew J., de Waal, Luc, McGaunn, Joseph, Kaplan, Bethany, Piccioni, Federica, Yang, Xiaoping, Lange, Martin, Tersteegen, Adrian, Raymond, Donald, Lewis, Timothy A., Carr, Steven A., Cherniack, Andrew D., Lemke, Christopher T., Meyerson, Matthew, Greulich, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285493/
https://www.ncbi.nlm.nih.gov/pubmed/34272366
http://dx.doi.org/10.1038/s41467-021-24495-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285493/
https://www.ncbi.nlm.nih.gov/pubmed/34272366
http://dx.doi.org/10.1038/s41467-021-24495-w

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