Evaluation of the Pharmacokinetics of Trazpiroben (TAK-906), a Peripherally Selective D(2)/D(3) Dopamine Receptor Antagonist, in the Presence and Absence of Itraconazole, a Potent CYP 3A4 Inhibitor

PURPOSE: Treatment options for gastroparesis, such as metoclopramide and domperidone, are limited because of safety concerns, which may be exacerbated in the presence of inhibitors of drug metabolism. This study evaluated the effect of itraconazole on the pharmacokinetics, safety, and tolerability o...

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Detalles Bibliográficos
Autores principales: Chen, Chunlin, Zhang, Wenwen, Bari, Muhammad, Almansa, Cristina, Baratta, Mike, Rosario, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Clinical Trial Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285519/
https://www.ncbi.nlm.nih.gov/pubmed/34285598
http://dx.doi.org/10.2147/CPAA.S310609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285519/
https://www.ncbi.nlm.nih.gov/pubmed/34285598
http://dx.doi.org/10.2147/CPAA.S310609

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