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Impact of cumulative fluid balance on the pharmacokinetics of extended infusion meropenem in critically ill patients with sepsis
BACKGROUND: Meropenem dosing for septic critically patients is difficult due to pathophysiological changes associated with sepsis as well as supportive symptomatic therapies. A prospective single-center study assessed whether fluid retention alters meropenem pharmacokinetics and the achievement of t...
Autores principales: | Pařízková, Renata Černá, Martínková, Jiřina, Havel, Eduard, Šafránek, Petr, Kaška, Milan, Astapenko, David, Bezouška, Jan, Chládek, Jaroslav, Černý, Vladimír |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285835/ https://www.ncbi.nlm.nih.gov/pubmed/34274013 http://dx.doi.org/10.1186/s13054-021-03680-9 |
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