A conserved epitope III on hepatitis C virus E2 protein has alternate conformations facilitating cell binding or virus neutralization

Epitope III, a highly conserved amino acid motif of (524)APTYSW(529) on the hepatitis C virus (HCV) E2 glycoprotein, resides in the critical loop that binds to the host receptor CD81, thus making it one of the most important antibody targets for blocking HCV infections. Here, we have determined the...

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Detalles Bibliográficos
Autores principales: Deng, Lu, Hernandez, Nancy, Zhong, Lilin, Holcomb, David D., Yan, Hailing, Virata, Maria Luisa, Tarafdar, Sreya, Xu, Yanqun, He, Yong, Struble, Evi, Alter, Harvey J., Zhang, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285954/
https://www.ncbi.nlm.nih.gov/pubmed/34260404
http://dx.doi.org/10.1073/pnas.2104242118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285954/
https://www.ncbi.nlm.nih.gov/pubmed/34260404
http://dx.doi.org/10.1073/pnas.2104242118

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