Regulation and drug modulation of a voltage-gated sodium channel: Pivotal role of the S4–S5 linker in activation and slow inactivation

Voltage-gated sodium (Na(V)) channels control excitable cell functions. While structural investigations have revealed conformation details of different functional states, the mechanisms of both activation and slow inactivation remain unclear. Here, we identify residue T140 in the S4–S5 linker of the...

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Detalles Bibliográficos
Autores principales: Xiao, Jinglei, Bondarenko, Vasyl, Wang, Yali, Suma, Antonio, Wells, Marta, Chen, Qiang, Tillman, Tommy, Luo, Yan, Yu, Buwei, Dailey, William P., Eckenhoff, Roderic, Tang, Pei, Carnevale, Vincenzo, Klein, Michael L., Xu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285963/
https://www.ncbi.nlm.nih.gov/pubmed/34260401
http://dx.doi.org/10.1073/pnas.2102285118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285963/
https://www.ncbi.nlm.nih.gov/pubmed/34260401
http://dx.doi.org/10.1073/pnas.2102285118

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