Identification of immune‐activating metabolite for enhancing T cell therapy of cancer

In this Research Highlight, we summarized the results from a study by Wu et al. published in Nature Cell Biology which uncovered that asparagine (Asn), a non‐essential amino acid in mammalians, is able to enhance the TCR‐mediated activation and efficacy of CD8(+) T cells towards tumour through lymph...

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Detalles Bibliográficos
Autores principales: Cong, Boyi, Cui, Zenghui, Cao, Xuetao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286139/
https://www.ncbi.nlm.nih.gov/pubmed/34004061
http://dx.doi.org/10.1002/cac2.12177
Descripción
Sumario:In this Research Highlight, we summarized the results from a study by Wu et al. published in Nature Cell Biology which uncovered that asparagine (Asn), a non‐essential amino acid in mammalians, is able to enhance the TCR‐mediated activation and efficacy of CD8(+) T cells towards tumour through lymphocyte‐specific protein tyrosine kinase (LCK) signalling. This study provides insights into the physiological function of Asn in T cell activation and effector functions, showing the encouraging possibility of key metabolites for empowering cancer immunotherapy. [Image: see text]

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