Identification of immune‐activating metabolite for enhancing T cell therapy of cancer

In this Research Highlight, we summarized the results from a study by Wu et al. published in Nature Cell Biology which uncovered that asparagine (Asn), a non‐essential amino acid in mammalians, is able to enhance the TCR‐mediated activation and efficacy of CD8(+) T cells towards tumour through lymph...

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Autores principales: Cong, Boyi, Cui, Zenghui, Cao, Xuetao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286139/
https://www.ncbi.nlm.nih.gov/pubmed/34004061
http://dx.doi.org/10.1002/cac2.12177
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author Cong, Boyi
Cui, Zenghui
Cao, Xuetao
author_facet Cong, Boyi
Cui, Zenghui
Cao, Xuetao
author_sort Cong, Boyi
collection PubMed
description In this Research Highlight, we summarized the results from a study by Wu et al. published in Nature Cell Biology which uncovered that asparagine (Asn), a non‐essential amino acid in mammalians, is able to enhance the TCR‐mediated activation and efficacy of CD8(+) T cells towards tumour through lymphocyte‐specific protein tyrosine kinase (LCK) signalling. This study provides insights into the physiological function of Asn in T cell activation and effector functions, showing the encouraging possibility of key metabolites for empowering cancer immunotherapy. [Image: see text]
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spelling pubmed-82861392021-07-21 Identification of immune‐activating metabolite for enhancing T cell therapy of cancer Cong, Boyi Cui, Zenghui Cao, Xuetao Cancer Commun (Lond) Research Highlight In this Research Highlight, we summarized the results from a study by Wu et al. published in Nature Cell Biology which uncovered that asparagine (Asn), a non‐essential amino acid in mammalians, is able to enhance the TCR‐mediated activation and efficacy of CD8(+) T cells towards tumour through lymphocyte‐specific protein tyrosine kinase (LCK) signalling. This study provides insights into the physiological function of Asn in T cell activation and effector functions, showing the encouraging possibility of key metabolites for empowering cancer immunotherapy. [Image: see text] John Wiley and Sons Inc. 2021-05-18 /pmc/articles/PMC8286139/ /pubmed/34004061 http://dx.doi.org/10.1002/cac2.12177 Text en © 2021 The Authors. Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat‐sen University Cancer Center https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Highlight
Cong, Boyi
Cui, Zenghui
Cao, Xuetao
Identification of immune‐activating metabolite for enhancing T cell therapy of cancer
title Identification of immune‐activating metabolite for enhancing T cell therapy of cancer
title_full Identification of immune‐activating metabolite for enhancing T cell therapy of cancer
title_fullStr Identification of immune‐activating metabolite for enhancing T cell therapy of cancer
title_full_unstemmed Identification of immune‐activating metabolite for enhancing T cell therapy of cancer
title_short Identification of immune‐activating metabolite for enhancing T cell therapy of cancer
title_sort identification of immune‐activating metabolite for enhancing t cell therapy of cancer
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286139/
https://www.ncbi.nlm.nih.gov/pubmed/34004061
http://dx.doi.org/10.1002/cac2.12177
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