Latest impact of engineered human liver platforms on drug development

Drug-induced liver injury (DILI) is a leading cause of drug attrition, which is partly due to differences between preclinical animals and humans in metabolic pathways. Therefore, in vitro human liver models are utilized in biopharmaceutical practice to mitigate DILI risk and assess related mechanism...

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Detalles Bibliográficos
Autores principales: Monckton, Chase P., Brown, Grace E., Khetani, Salman R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286174/
https://www.ncbi.nlm.nih.gov/pubmed/34286173
http://dx.doi.org/10.1063/5.0051765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286174/
https://www.ncbi.nlm.nih.gov/pubmed/34286173
http://dx.doi.org/10.1063/5.0051765

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