Cargando…

DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65

Parkinson’s disease (PD), one of the most common neurodegenerative disorders, is characterized by progressive neurodegeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). DJ-1 acts essential roles in neuronal protection and anti-neuroinflammatory response, and its los...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Zixuan, Chen, Chen, Yang, Dongqin, Ding, Jianqing, Wang, Guanghui, Ren, Haigang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286256/ https://www.ncbi.nlm.nih.gov/pubmed/34274951 http://dx.doi.org/10.1038/s41419-021-04002-1

Ejemplares similares

P7C3 Inhibits LPS-Induced Microglial Activation to Protect Dopaminergic Neurons Against Inflammatory Factor-Induced Cell Death in vitro and in vivo
por: Gu, Chao, et al.
Publicado: (2018)

Diosgenin Prevents Microglial Activation and Protects Dopaminergic Neurons from Lipopolysaccharide-Induced Neural Damage In Vitro and In Vivo
por: Lee, Shou-Lun, et al.
Publicado: (2021)

Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation
por: Liu, Jie, et al.
Publicado: (2015)

Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase
por: Jiang, Lulu, et al.
Publicado: (2016)

Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation
por: Zhang, Ruiping, et al.
Publicado: (2011)

Cytokine Profiling in Human iPSC-Derived Dopaminergic Neuronal and Microglial Cultures
por: Knappe, Evelyn, et al.
Publicado: (2023)

The role of DJ-1 in anti-apoptosis
por: Ren, Haigang, et al.
Publicado: (2012)

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo
por: Barcia, Carlos, et al.
Publicado: (2012)

P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo
por: Gu, Chao, et al.
Publicado: (2017)

JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss
por: Wang, Qing, et al.
Publicado: (2018)

Down-regulation of microglial activity attenuates axotomized nigral dopaminergic neuronal cell loss
por: Song, Dae-Yong, et al.
Publicado: (2013)

DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson’s disease
por: Kinugawa, Kiyoka, et al.
Publicado: (2013)

Olfactory Sensory Activity Modulates Microglial-Neuronal Interactions during Dopaminergic Cell Loss in the Olfactory Bulb
por: Grier, Bryce D., et al.
Publicado: (2016)

Taurine protects dopaminergic neurons in a mouse Parkinson’s disease model through inhibition of microglial M1 polarization
por: Che, Yuning, et al.
Publicado: (2018)

Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits
por: Wang, Tzu-Feng, et al.
Publicado: (2022)

Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies
por: Asraf, Keren, et al.
Publicado: (2018)

Microglial control of neuronal activity
por: Béchade, Catherine, et al.
Publicado: (2013)

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
por: Guzman, Jaime N., et al.
Publicado: (2010)

Licochalcone A Prevents the Loss of Dopaminergic Neurons by Inhibiting Microglial Activation in Lipopolysaccharide (LPS)-Induced Parkinson’s Disease Models
por: Huang, Bingxu, et al.
Publicado: (2017)

1α,25-Dihydroxyvitamin D(3) Protects Dopaminergic Neurons in Rodent Models of Parkinson's Disease through Inhibition of Microglial Activation
por: Kim, Joong-Seok, et al.
Publicado: (2006)

Neuronal and microglial mechanisms of neuropathic pain
por: Zhuo, Min, et al.
Publicado: (2011)

In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord
por: Morsch, Marco, et al.
Publicado: (2015)

Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro
por: Cadiz, Mika P., et al.
Publicado: (2022)

Microglial subtypes: diversity within the microglial community
por: Stratoulias, Vassilis, et al.
Publicado: (2019)

Quercetin and Sesamin Protect Dopaminergic Cells from MPP(+)-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System
por: Bournival, Julie, et al.
Publicado: (2012)

Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression
por: Wang, Yong, et al.
Publicado: (2020)

Pyruvate Dehydrogenase Kinase Protects Dopaminergic Neurons from Oxidative Stress in Drosophila DJ-1 Null Mutants
por: Lee, Yoonjeong, et al.
Publicado: (2022)

Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson’s disease
por: Cai, Hua-Ying, et al.
Publicado: (2021)

Salidroside Protects Dopaminergic Neurons by Preserving Complex I Activity via DJ-1/Nrf2-Mediated Antioxidant Pathway
por: Li, Ruru, et al.
Publicado: (2019)

Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function
por: Li, Qijun, et al.
Publicado: (2014)

Analysis of the Direct and Indirect Effects of Nanoparticle Exposure on Microglial and Neuronal Cells In Vitro
por: Lojk, Jasna, et al.
Publicado: (2020)

Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice
por: Yamaguchi, Hiroo, et al.
Publicado: (2007)

DJ-1 Regulates Microglial Polarization Through P62-Mediated TRAF6/IRF5 Signaling in Cerebral Ischemia-Reperfusion
por: Wang, Tingting, et al.
Publicado: (2020)

trans-Cinnamaldehyde Inhibits Microglial Activation and Improves Neuronal Survival against Neuroinflammation in BV2 Microglial Cells with Lipopolysaccharide Stimulation
por: Fu, Yan, et al.
Publicado: (2017)

Microglial pathology
por: Streit, Wolfgang J, et al.
Publicado: (2014)

Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation
por: Cao, Mingju, et al.
Publicado: (2015)

Involvement of the Bradykinin B(1) Receptor in Microglial Activation: In Vitro and In Vivo Studies
por: Asraf, Keren, et al.
Publicado: (2017)

Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathway
por: Wu, Jin, et al.
Publicado: (2023)

Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson’s Disease
por: Okuyama, Satoshi, et al.
Publicado: (2016)

The role of microglial exosomes in brain injury
por: Chen, Yahong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f9aeh33a8qglgf83fisrvnthie