Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia

Human iPSC lines represent a powerful translational model of tauopathies. We have recently described a pathophysiological phenotype of neuronal excitability of human cells derived from the patients with familial frontotemporal dementia and parkinsonism (FTDP-17) caused by the MAPT 10+16 splice-site...

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Detalles Bibliográficos
Autores principales: Kopach, Olga, Esteras, Noemí, Wray, Selina, Abramov, Andrey Y., Rusakov, Dmitri A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286258/
https://www.ncbi.nlm.nih.gov/pubmed/34274950
http://dx.doi.org/10.1038/s41419-021-04007-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286258/
https://www.ncbi.nlm.nih.gov/pubmed/34274950
http://dx.doi.org/10.1038/s41419-021-04007-w

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