Efficacy of computational predictions of the functional effect of idiosyncratic pharmacogenetic variants

BACKGROUND: Pharmacogenetic variation is important to drug responses through diverse and complex mechanisms. Predictions of the functional impact of missense pharmacogenetic variants primarily rely on the degree of sequence conservation between species as a primary discriminator. However, idiosyncra...

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Detalles Bibliográficos
Autores principales: McConnell, Hannah, Andrews, T. Daniel, Field, Matt A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286708/
https://www.ncbi.nlm.nih.gov/pubmed/34316407
http://dx.doi.org/10.7717/peerj.11774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286708/
https://www.ncbi.nlm.nih.gov/pubmed/34316407
http://dx.doi.org/10.7717/peerj.11774

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