Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

The precise mechanistic action of acetaminophen (ACT; paracetamol) remains debated. ACT’s analgesic and antipyretic actions are attributed to cyclooxygenase (COX) inhibition preventing prostaglandin (PG) synthesis. Two COX isoforms (COX1/2) share 60% sequence structure, yet their functions vary. COX...

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Detalles Bibliográficos
Autores principales: Esh, Christopher J., Chrismas, Bryna C. R., Mauger, Alexis R., Taylor, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287062/
https://www.ncbi.nlm.nih.gov/pubmed/34278737
http://dx.doi.org/10.1002/prp2.835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287062/
https://www.ncbi.nlm.nih.gov/pubmed/34278737
http://dx.doi.org/10.1002/prp2.835

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