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Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?
The precise mechanistic action of acetaminophen (ACT; paracetamol) remains debated. ACT’s analgesic and antipyretic actions are attributed to cyclooxygenase (COX) inhibition preventing prostaglandin (PG) synthesis. Two COX isoforms (COX1/2) share 60% sequence structure, yet their functions vary. COX...
Autores principales: | Esh, Christopher J., Chrismas, Bryna C. R., Mauger, Alexis R., Taylor, Lee |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287062/ https://www.ncbi.nlm.nih.gov/pubmed/34278737 http://dx.doi.org/10.1002/prp2.835 |
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