Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-β(1) are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa

RESEARCH QUESTION: Pulmonary disease progression in patients with cystic fibrosis (CF) is characterised by inflammation and fibrosis and aggravated by Pseudomonas aeruginosa (Pa). We investigated the impact of Pa specifically on: 1) protease/antiprotease balance; 2) inflammation; and 3) the link of...

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Detalles Bibliográficos
Autores principales: Thomassen, Jan C., Trojan, Tobias, Walz, Maxine, Vohlen, Christina, Fink, Gregor, Rietschel, Ernst, Alejandre Alcazar, Miguel A., van Koningsbruggen-Rietschel, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287132/
https://www.ncbi.nlm.nih.gov/pubmed/34291109
http://dx.doi.org/10.1183/23120541.00636-2020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287132/
https://www.ncbi.nlm.nih.gov/pubmed/34291109
http://dx.doi.org/10.1183/23120541.00636-2020

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