Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes

Axonal generation of Alzheimer’s disease (AD)-associated amyloid-β (Aβ) plays a key role in AD neuropathology, but the cellular mechanisms involved in its release have remained elusive. We previously reported that palmitoylated APP (palAPP) partitions to lipid rafts where it serves as a preferred su...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Raja, Black, Sophia E., Lotlikar, Madhura S., Fenn, Rebecca H., Jorfi, Mehdi, Kovacs, Dora M., Tanzi, Rudolph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287518/
https://www.ncbi.nlm.nih.gov/pubmed/34010653
http://dx.doi.org/10.1016/j.celrep.2021.109134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287518/
https://www.ncbi.nlm.nih.gov/pubmed/34010653
http://dx.doi.org/10.1016/j.celrep.2021.109134

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