Cargando…

E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points

Proteolysis-targeting chimeras (PROTACs) have received tremendous attention as a new and exciting class of therapeutic agents that promise to significantly impact drug discovery. These bifunctional molecules consist of a target binding unit, a linker, and an E3 ligase binding moiety. The chemically-...

Descripción completa

Detalles Bibliográficos
Autores principales: Bricelj, Aleša, Steinebach, Christian, Kuchta, Robert, Gütschow, Michael, Sosič, Izidor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287636/
https://www.ncbi.nlm.nih.gov/pubmed/34291038
http://dx.doi.org/10.3389/fchem.2021.707317