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E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points
Proteolysis-targeting chimeras (PROTACs) have received tremendous attention as a new and exciting class of therapeutic agents that promise to significantly impact drug discovery. These bifunctional molecules consist of a target binding unit, a linker, and an E3 ligase binding moiety. The chemically-...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287636/ https://www.ncbi.nlm.nih.gov/pubmed/34291038 http://dx.doi.org/10.3389/fchem.2021.707317 |