CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity

BACKGROUND: CMTM7 is a tumor suppressor that positively regulates EGFR degradation by promoting Rab5 activation, and plays a vital role in tumor progression. Rab5 forms complexes with Beclin1 and VPS34, and acts in the early stage of autophagy. However, the affects of CMTM7 on autophagy and its mech...

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Detalles Bibliográficos
Autores principales: Liu, Baocai, Lu, Yinliang, Zhang, Tingting, Yu, Xinyue, Wang, Qian, Chi, Yunbo, Jin, Shunzi, Cheng, Guanghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287682/
https://www.ncbi.nlm.nih.gov/pubmed/34281589
http://dx.doi.org/10.1186/s12964-021-00720-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287682/
https://www.ncbi.nlm.nih.gov/pubmed/34281589
http://dx.doi.org/10.1186/s12964-021-00720-3

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