Reducing Auditory Nerve Excitability by Acute Antagonism of Ca(2+)-Permeable AMPA Receptors

Hearing depends on glutamatergic synaptic transmission mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). AMPARs are tetramers, where inclusion of the GluA2 subunit reduces overall channel conductance and Ca(2+) permeability. Cochlear afferent synapses between inner...

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Detalles Bibliográficos
Autores principales: Walia, Amit, Lee, Choongheon, Hartsock, Jared, Goodman, Shawn S., Dolle, Roland, Salt, Alec N., Lichtenhan, Jeffery T., Rutherford, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287724/
https://www.ncbi.nlm.nih.gov/pubmed/34290596
http://dx.doi.org/10.3389/fnsyn.2021.680621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287724/
https://www.ncbi.nlm.nih.gov/pubmed/34290596
http://dx.doi.org/10.3389/fnsyn.2021.680621

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