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Reducing Auditory Nerve Excitability by Acute Antagonism of Ca(2+)-Permeable AMPA Receptors
Hearing depends on glutamatergic synaptic transmission mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). AMPARs are tetramers, where inclusion of the GluA2 subunit reduces overall channel conductance and Ca(2+) permeability. Cochlear afferent synapses between inner...
Autores principales: | Walia, Amit, Lee, Choongheon, Hartsock, Jared, Goodman, Shawn S., Dolle, Roland, Salt, Alec N., Lichtenhan, Jeffery T., Rutherford, Mark A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287724/ https://www.ncbi.nlm.nih.gov/pubmed/34290596 http://dx.doi.org/10.3389/fnsyn.2021.680621 |
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