Cargando…

Claudin-7 deficiency promotes stemness properties in colorectal cancer through Sox9-mediated Wnt/β-catenin signalling

BACKGROUND: Colorectal cancer (CRC) is a common malignant tumour of the digestive tract that is characterized by high patient morbidity and mortality rates. Claudin-7 (Cldn7), a tight junction protein, was recently reported to function as a candidate tumour suppressor gene in CRC. Our previous study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Chang, Ding, Yu-han, Wang, Kun, Hao, Mengdi, Li, Huimin, Ding, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287764/ https://www.ncbi.nlm.nih.gov/pubmed/34281572 http://dx.doi.org/10.1186/s12967-021-02983-3

Ejemplares similares

Intestinal Claudin-7 deficiency impacts the intestinal microbiota in mice with colitis
por: Ding, Yuhan, et al.
Publicado: (2022)

Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling
por: Leung, Carmen Oi-Ning, et al.
Publicado: (2016)

Claudin-7 Inhibits Proliferation and Metastasis in Salivary Adenoid Cystic Carcinoma Through Wnt/β-Catenin Signaling
por: Ji, Huan, et al.
Publicado: (2020)

SOX9 and TCF transcription factors associate to mediate Wnt/β-catenin target gene activation in colorectal cancer
por: Ramakrishnan, Aravinda-Bharathi, et al.
Publicado: (2022)

SOX9 drives the epithelial–mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway
por: Huang, Jing-Qiang, et al.
Publicado: (2019)

Repression of Wnt/β-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2
por: Sinha, Abhishek, et al.
Publicado: (2021)

Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer
por: Li, Zhengguang, et al.
Publicado: (2023)

Corrigendum to “Claudin-7 Inhibits Proliferation and Metastasis in Salivary Adenoid Cystic Carcinoma Through Wnt/β-Catenin Signaling”
Publicado: (2021)

Expression and Clinical Significance of Claudin-7 in Patients With Colorectal Cancer
por: Xu, Chang, et al.
Publicado: (2018)

Down-regulation of Sox7 is associated with aberrant activation of Wnt/β-catenin signaling in endometrial cancer
por: Chan, David W, et al.
Publicado: (2012)

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer
por: Yao, Hanhui, et al.
Publicado: (2022)

Emerging clinical significance of claudin-7 in colorectal cancer: a review
por: Wang, Kun, et al.
Publicado: (2018)

TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer
por: Tang, Qiang, et al.
Publicado: (2020)

Interplay Between SOX9, Wnt/β-Catenin and Androgen Receptor Signaling in Castration-Resistant Prostate Cancer
por: Khurana, Namrata, et al.
Publicado: (2019)

The function of BCL9 in Wnt/β-catenin signaling and colorectal cancer cells
por: de la Roche, Marc, et al.
Publicado: (2008)

MicroRNA-452 promotes stem-like cells of hepatocellular carcinoma by inhibiting Sox7 involving Wnt/β-catenin signaling pathway
por: Zheng, Zhiyun, et al.
Publicado: (2016)

Non-tight junction-related function of claudin-7 in interacting with integrinβ1 to suppress colorectal cancer cell proliferation and migration
por: Li, Wenjing, et al.
Publicado: (2019)

SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ß-catenin signaling
por: Prévostel, Corinne, et al.
Publicado: (2016)

SOX8 promotes tumor growth and metastasis through FZD6-dependent Wnt/β-catenin signaling in colorectal carcinoma
por: Li, Chen, et al.
Publicado: (2023)

Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
por: Jung, Youn-Sang, et al.
Publicado: (2015)

SOX9 in Keratinocytes Regulates Claudin 2 Transcription during Skin Aging
por: Wang, Jingyan, et al.
Publicado: (2022)

Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/β-catenin signaling pathway
por: Liu, Huidi, et al.
Publicado: (2014)

SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer
por: Liu, Huidi, et al.
Publicado: (2016)

Wnt/β-catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer
por: Zhu, Gui-Xian, et al.
Publicado: (2021)

Cldn-7 deficiency promotes experimental colitis and associated carcinogenesis by regulating intestinal epithelial integrity
por: Wang, Kun, et al.
Publicado: (2021)

A SOX9‐AS1/miR‐5590‐3p/SOX9 positive feedback loop drives tumor growth and metastasis in hepatocellular carcinoma through the Wnt/β‐catenin pathway
por: Zhang, Wei, et al.
Publicado: (2019)

Long noncoding RNA AB073614 promotes the malignance of glioma by activating Wnt/β-catenin signaling through downregulating SOX7
por: Li, Yuqian, et al.
Publicado: (2017)

SOX9 knockout decreases stemness properties in colorectal cancer cells
por: Avendaño-Felix, Mariana, et al.
Publicado: (2023)

Odd‐skipped related 1 inhibits lung cancer proliferation and invasion by reducing Wnt signaling through the suppression of SOX9 and β‐catenin
por: Wang, Yuan, et al.
Publicado: (2018)

Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer
por: Bian, Jia, et al.
Publicado: (2020)

Loss of zfp36 expression in colorectal cancer correlates to wnt/ β-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1
por: Montorsi, Lucia, et al.
Publicado: (2016)

KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling
por: Li, Jiong, et al.
Publicado: (2017)

Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer
por: Wei, Jinlai, et al.
Publicado: (2022)

Tuning WNT-β-catenin signaling via BCL9 proteins for targeting colorectal cancer cells
por: Beaulieu, Jean-François
Publicado: (2015)

Clinical significance of serum claudin-1 and claudin-7 levels in patients with colorectal cancer
por: KARABULUT, MEHMET, et al.
Publicado: (2015)

Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells
por: He, Jinxi, et al.
Publicado: (2017)

Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network
por: Mukherjee, Shreyasi, et al.
Publicado: (2020)

Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth
por: Uka, Rexhep, et al.
Publicado: (2020)

LINC00115 promotes stemness and inhibits apoptosis of ovarian cancer stem cells by upregulating SOX9 and inhibiting the Wnt/β-catenin pathway through competitively binding to microRNA-30a
por: Hou, Rui, et al.
Publicado: (2021)

SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells
por: Mukherjee, Shreyasi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k0t5kp631ncr277410cb53rfld